Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states
The Notch signaling pathway consists of multiple types of receptors and ligands, whose interactions can be tuned by Fringe glycosyltransferases.A major challenge is to determine how these components control Me 4th of July Top the specificity and directionality of Notch signaling in developmental contexts.Here, we analyzed same-cell (cis) Notch-liga